Steve Murphy is a DEA agent, and along with his new partner, Javier Peña, is assigned the task to eliminate drug threats (by themselves or in conjunction with local law enforcement). They are part of the ground team that executes orders for the Drug Enforcement Administration. Pablo Escobar (Wagner Moura) is connected with a cocaine chemist known as Cockroach from Chile. Together they build their empire, planning and executing new ways of trafficking drugs to and from Cuba and supplying the content to Miami (Florida). After getting betrayed by Cockroach, Pablo takes revenge on him.